Detrol LA and Pregnancy
From Pharmacy Drug Guide
Little is known about the potential risks of Detrol LA for pregnant women or their unborn babies. The manufacturer recommends that women inform their physicians if they are pregnant or are planning to conceive a child. It is also not know whether Detrol LA can be passed to infants through the mother's breast milk.[1]
Detrol LA, a brand name for the extended release formula of tolterodine tartrate, is an anticholinergic prescription medication which helps control overactive bladder, otherwise known as urge incontinence, irritable bladder, or bladder spasms. Overactive bladder is a condition where the bladder muscles contract inappropriately, before the bladder contains a significant quantity of urine. It causes unusually frequent urination, involuntary urination, and an urgent need to urinate. Patients may be woken up frequently during the night due to a need to urinate. Overactive bladder may be caused by neurological problems or bladder injury.[2] [3] Detrol LA is a 24-hour time release formula which helps control the bladder muscles and prevent these symptoms.[2]
Some patients with stomach problems, constipation, glaucoma, and myasthenia gravis may be unable to use Detrol LA. Detrol LA has been known to cause constipation, headache, abdominal pain, or dry mouth in some patients.[2] [4]
 Flickr: david_shankbone | |
| Brand name for | Tolterodine tartrate |
|---|---|
| Used for | Overactive bladder |
| Pregnancy Risk Factor | C |
| Label instructions | The recommended dose is 4 mg once per day. This may be reduced to 2 mg once per day as needed.[4] |
| Warnings | Detrol LA should be used during pregnancy only if the potential benefit for the mother justifies the potential risk to the fetus. Detrol LA should not be administered during nursing.[4] |
| Disclaimer | The information provided by PharmacyDrugGuide.com is not a substitute for professional medical advice, diagnosis, or treatment. Do not take any action based on the information on this page without consulting a physician. |
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Detrol LA and Pregnancy
Detrol LA has not been tested in pregnant women. Animal studies have demonstrated some risks. Category C medications are usually not recommended for use during pregnancy; however, they may be prescribed for a pregnant woman if the health care provider determines that its benefits outweigh the possible risks to the unborn child.[5]
Pregnant mice were given Detrol LA at nine to 12 times the level of a normal dosage. No adverse effects on the mother and child were reported in these amounts. In another study, pregnant mice were administered 14 to 18 times the normal dosage. At these rates, the drug caused low birth weight and killed some babies. There were also abnormalities like cleft palate, abdominal hemorrhage, and abnormalities of the skeleton, fingers and toes. Rabbits were also tested with 0.3 to 2.5 the typical Detrol LA dosage, and did not show any birth defects.[5]
Detrol LA and Breastfeeding
In animal studies, Detrol LA passed into the milk of lactating mice. Similar studies for humans have not been performed. Based on the results of the animal studies, the National Institutes of Health (NIH) and Pfizer, the manufacturer, recommend that nursing women refrain from using Detrol LA. Women who need to use the drug are advised to seek other feeding options, such as formulas.[5] [4]
Prescription Drugs
Also See: Drugs and Pregnancy, Detrol LA Side Effects, Pfizer Patient Assistance Programs, Prescription Drugs, Drug Side Effects, Tylenol and Pregnancy, Marijuana and Pregnancy, Ambien and Pregnancy, Botox and Pregnancy
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References
- ↑ http://www.detrolla.com/SideEffects.aspx
- ↑ 2.0 2.1 2.2 http://www.detrolla.com/AboutDetrolLA.aspx
- ↑ http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002250/
- ↑ 4.0 4.1 4.2 4.3 http://www.pfizer.com/files/products/uspi_detrol_la.pdf
- ↑ 5.0 5.1 5.2 http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=15875
