Prolia Side Effects
From Pharmacy Drug Guide
Prolia is a brand of denosumab injection, a prescription medication used to treat osteoporosis in post-menopausal women with increased risk of fractures. Prolia is also prescribed to treat bone loss in patients receiving certain cancer treatments that can cause an increased risk of bone fractures. Among cancer patients, Prolia is used most often in men with prostate cancer and in women with breast cancer.[1] Patients receive a 60mg injection of Prolia every six months and follow a daily regimen of taking calcium and vitamin D.[2]
Common Prolia side effects include muscle pain, back pain, and joint pain. In clinical studies, patients who chose to discontinue using Prolia listed symptoms of back pain and constipation as reasons for stopping.[1]
 Cross section of human hip bone, Flickr: Patrick Siemer | |
| Brand name for | Denosumab injection |
|---|---|
| Manufacturer | Amgen, Inc. |
| Uses | Increases bone mass in patients with prostate and breast cancer, and women with osteoporosis |
| Common side effects | Back pain, muscle pain and constipation |
| Who should not take Prolia? | Patients taking Xgeva, which also contains denosumab |
| Disclaimer | The information provided by PharmacyDrugGuide.com is not a substitute for professional medical advice, diagnosis, or treatment. Do not take any action based on the information on this page without consulting a physician. |
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Common Prolia Side Effects
Common Prolia side effects include back pain, muscle pain, joint pain, constipation, bladder infections, and increased cholesterol levels.[3] [1]
Skin maladies are also common while taking Prolia, and users may experience red, dry, itchy skin; rash; oozing or crusty blisters on skin; or peeling skin. Skin conditions that become infected may need to be treated by a doctor.[4]
Possible serious side effects, which may require immediate medical attention, include low blood calcium levels (hypocalcemia), severe jaw bone problems (osteonecrosis), and serious abdominal or ear infections.[3] Prolia has also been known to cause endocarditis, or inflammation of the inner lining of the heart.[3]
About Drug Side Effects
Prolia Allergic Reactions
The use of Prolia is contraindicated for patients with a known hypersensitivity or allergy to denosumab or to any of the following inactive ingredients: sodium acetate, polysorbate 20, and sorbitol.
Prolia is prepared as a single-dose, prefilled syringe for subcutaneous use. The Prolia syringe contains dry natural rubber, which may be an allergen for certain patients. The rubber is a latex derivative, so those with latex allergies are susceptible to reactions.[1]
Prolia Precautions and Warnings
- Prolia is contraindicated for patients who:
- have low blood calcium
- have kidney problems or are on dialysis
- cannot take calcium or vitamin D, or have difficulty absorbing those minerals (malabsorption syndrome)
- have had thyroid or parathyroid surgery[3]
- Prolia can cause complications of the jaw, which is more likely if patients undergo dental surgery during treatment.[4]
- Prolia is falls under FDA pregnancy category C. Prolia has not been adequately tested on humans; however, animal reproduction studies have shown an adverse effect on the fetus. While it is not known if Prolia can harm an unborn baby or if Prolia can pass through breast milk in nursing mothers, animal studies in pregnant mice showed impaired lactation postpartum. [1]
- Patients taking Prolia must get a minimum of 1000mg of calcium and 400 IU of vitamin D every day.[1]
- Prolia can cause reactions when taken with a number of prescription and nonprescription drugs and supplements. These include blood thinners like herapin, chemotherapy drugs, seizure drugs like phenytoin, immune suppressors, vitamin A, and oral steroids like prednisone.[1]
- Prolia may not be right for patients with history of anemia.[1]
- Prolia can affect the development of teeth if used by children, and may hinder their bone growth.[1]
Also See: Arimidex, Arimidex Coupons, Arimidex Free Samples, Arimidex Patient Assistance Programs, Boniva Side Effects, Boniva Coupons, Avastin Side Effects, Breast Cancer Awareness Month, Herceptin Side Effects
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References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=49e5afe9-a0c7-40c4-af9f-f287a80c5c88
- ↑ http://www.nlm.nih.gov/medlineplus/druginfo/meds/a610023.html
- ↑ 3.0 3.1 3.2 3.3 http://www.prolia.com/one-shot-every-six-months/benefits.html
- ↑ 4.0 4.1 http://www.nlm.nih.gov/medlineplus/druginfo/meds/a610023.html#side-effects
